Antibody Humanization Service

Research in the production of monoclonal antibodies is a key part of antibody humanization. The process of converting murine antibodies into human antibodies is called antibody humanization. 


Initial monoclonal antibody used in clinical practice was mouse-derived monoclonal antibodies. However, there were limitations to using mouse-derived antibodies because of differences in human and mouse species. While murine antibodies can bind to specific target antigens and are able to bind to them, they do not activate human immune system such as complement-dependent cytotoxicity and antibody-dependent cell-mediated cytotoxicity (CDC). Therefore, antigen-antibody reactions cannot take place normally. However, murine antibodies that enter the human body may be considered exogenous proteins. This can cause the immune system to produce specific antibodies using mouse antigens (i.e. Human anti-mo...

Quality Service; -- Advanced Algorithm for Aligning and Grafting of CDRs Affinity Guarantee

-- Antibody humanization from a broad range of parental species including mouse, rat, rabbit, llama and avian scFvs, Fabs and other antibodies humanized

-- A human antibody database and a proprietary method are used to analyze and design humanized antibodies.

-- Flexible packages to work in synergy with your team: choose the number of humanized variants you would like to design from 9 to 25 combinations of VH and VL sequences.

services

United States

US$