Particle Size Reduction of Active Pharmaceutical Ingredients (API ). The wet milling technology of WAB allows for effectively reducing the particle size of API and excipients. With the DYNO®-MILL PHARMA equipment, coarse particles are milled to establish the required particle size distribution. The DYNO®-MILL PHARMA equipment line is capable of mechanical Micronization and Nanosization at current Good Manufacturing Practice (cGMP) level protocols. Realised through semi-automatic or fully automatic control units, and the 21 CFR part 11 compliant WAB SCADA-System. In addition, selected DYNO®-MILL PHARMA units are available with Cleaning-In-Place (CIP) and Sterilization-In-Place (SIP) functionality. WAB supports its customers with great attention to detail from the initial definition of the User Requirement Specification (URS) throughout the IQ/OQ.