TMC435 Proven Effective for Hepatitis C
Medivir announces positive 48-week interim data from TMC435 hepatitis C Phase IIb study.
Medivir has announced positive results from a Phase IIb study of TMC435 in patients with genotype 1 chronic hepatitis C.
The randomised, placebo-controlled, double-blind study included 462 patients who have relapsed, achieved partial response, or achieved no response to standard of care treatment.
Interim 48-week data revealed that 94% of patients treated with TMC435 showed sustained virologic response, compared to 84% for placebo.
TMC435 treated patients achieved undetectable HCV RNA levels, mild and reversible increases in bilirubin and decrease in mean alanine aminotransferase levels.
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