Amgen & UCB Announce Positive Phase 2 Results of AMG 785/CDP7851
Amgen and UCB have announced positive results from a phase II study of their new postmenopausal osteoporosis treatment.
Amgen and UCB (Euronext Brussels) has received positive top-line results from their Phase 2 clinical study comparing sclerostin-antibody AMG 785/CDP7851 to placebo in postmenopausal women with low bone mineral density (BMD) for the treatment of postmenopausal osteoporosis (PMO).
AMG 785/CDP7851 is a humanized monoclonal antibody that binds to and inhibits sclerostin, a protein secreted by bone cells that inhibits bone formation. By binding to and blocking sclerostin, AMG 785/CDP7851 is designed to allow the body to add more bone to the skeleton. Amgen and UCB have collaborated for the development of AMG 785/CDP7851 for the treatment of bone-related conditions, including PMO and fracture healing.
The Phase 2 study met its primary endpoint, demonstrating significant increases in lumbar
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