Bivalirudin

Fields of Application: Premature labor. Atosiban is an oxytocin and vasopressin antagonist. It is used as a tocolytic in the management of preterm labor.

Fields of Application: Use in reproduction medicine. Advanced hormone-dependent prostate cancer Endometriosis, Central precocious puberty, Uterine myoma. Buserelin is a potent LHRH agonist. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.

Fields of Application: Nocturnal enuresis, Central diabetes insipidus, polyuria, polydipsia, Mild and moderate forms of hemophilia A and von Willebrand disease. Desmopressin is a synthetic analog of vasopressin with low vasopressor activity. Apart from its increasing effect on water resorption by the kidneys, it raises plasma levels of von Willebrand factor and factor VIII.In veterinary medicine, desmopressin is applied in the treatment of canine and feline diabetes insipidus.

Fields of Application: Hypoglycemia (due to diabetes mellitus). Glucagon opposes the action of insulin. It enhances the synthesis and mobilization of glucose in the liver.

Fields of Application: Ovarian follicular cysts (veterinary medicine), Use in reproduction medicine, Diagnosis of the hypothalamic-pituitary-gonadal axis function, Cryptorchism, Synchronization of ovulation (veterinary medicine). Gonadorelin is also known as LHRH or GnRH.After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.

Fields of Application: Advanced hormone-dependent prostate cancer, Advanced hormone-dependent breast cancer, Endometriosis, Uterine myoma, Use in reproductive medicine. Goserelin Acetate is a potent LHRH agonist. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.

Fields of Application: Acromegaly, Carcinoid syndrome, Thyrotrophic adenomas. Lanreotide is a synthetic analog of somatostatin with properties similar to octreotide.

Fields of Application: Advanced hormone-dependent prostate cancer, Advanced hormone-dependent breast cancer, Endometriosis, Uterine myoma, Central precocious puberty. Leuprolide Acetate is a potent LHRH agonist. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.

Fields of Application: Acromegaly, Carcinoid syndrome, VIPomas. Octreotide Acetate is a longer acting synthetic octapeptide analog of naturally occurring somatostatin. It inhibits the secretion of gastro-entero-pancreatic peptide hormones and the release of growth hormone.

Fields of Application: Osteoporosis - not yet an approved application. pTH (1-34) (human) Acetate administered in low dosage and intermittently stimulates bone formation.

Fields of Application: Ulcer bleeding, Hemorrhagic gastritis, Postoperative pancreatic and duodenal fistulae, Variceal hemorrhage. Somatostatin is an inhibitor of growth hormone release from the anterior pituitary and suppresses the release of a variety of other hormones involved in the regulation of important physiological functions of the gastrointestinal tract.

Fields of Application: Investigation of adrenocortical insufficiency, Neurological diseases, Rheumatic diseases, Skin diseases, Diseases of the intestinal tract, Oncology. Tetracosactide is a synthetic peptide that corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). It stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.In veterinary medicine, tetracosactide (cosyntropin) is used as a diagnostic for detecting adrenal disorders in dogs, horses, and cats.

In our studies in collaboration with Novo Nordisk, we set out to identify environmentally benign solvents suitable for large-scale SPPS of peptide therapeutics at ambient temperature by assessing reagent solubility, resin swelling, amino acid coupling and Fmoc-removal efficiency in a collection of REACH compatible neat solvents and selected binary solvent mixtures. These studies have shown that binary solvent mixtures are indeed viable alternatives.

The Molecular Hiving™️ technology is especially suitable for the synthesis of peptide ingredients for cosmetic products, as CMR solvents and reagents can entirely be avoided during the manufacturing process.

If you’re looking for news, product information and market trends from leading pharma companies, the CPhI-Online.com Company Showcases are a great resource for buyers who want to stay up to date, browse product portfolios and find the right partner. 

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The Bachem Group (SIX: BANB) today announced measures and decisions designed to ensure that the global market is kept supplied with the active pharmaceutical ingredient Propofol from its Swiss production site in Vionnaz.

Peptide APIs obtained by solid-phase synthesis may additionally contain analogs resulting from deletion or double insertion of amino acids. References of such compounds are needed for analytical method development and release testing.

Bachem is the leading independent supplier of active pharmaceutical ingredients (APIs) for the human and veterinary pharmaceutical market. Check our portfolio of generic APIs, which are produced in annual quantities of up to hundreds of kilograms and tons for commercial use.

Microparticle formulation has been successfully applied in a number of commercial products containing peptides as APIs. The use of nanoparticles for delivering proteins and peptides are still in early stages of development. Discover how Bachem is part of this technology!

Like all drug substance material, synthetic peptides manufactured under GMP conditions require stringent analytical tests for release and use in humans for clinical trials and approved treatments.

Long or strongly hydrophobic peptides may aggregate and become challenging to handle, either for further chemical reactions or for purification. PEC platform represents an opportunity to overcome these drawbacks and may facilitate and/or accelerate the purification process.

An in-depth look at the Japanese Pharma market. Hear from Associations and Analysts on market potential, challenges and opportunities, and from pharma companies who have successfully built a business in the market. Aired as part of the CPhI Festival of pharma

Learn about the Molecular HivingTM technology, it’s scalability and the substantial advantages regarding efficiency, CMR free synthesis of peptides and greener manufacturing.

Amy Zhang, the Head of Supply Chain at Luye Pharma, recently spoke with us about her experience working with Bachem.