Bosch Presents CIP System at TechnoPharm
At TechnoPharm 2014, Bosch Packaging Technology presents the special version of a CIP (Cleaning in Place) system. “The exhibited system serves for cleaning and wastewater inactivation of various process systems used in the production of human vaccines,” explained project manager Volker Kempf. “It meets the highest safety requirements. In addition, it is easy to transport, quick to set up, and easy to handle.” The CIP system is manufactured by Pharmatec, a subsidiary of Bosch Packaging Technology.
The development of human vaccines comprises three successive process steps: preparation, purification, and formulation. During the first phase, eggs are inoculated with virus-containing material for selective replication of viruses in the laboratory. To separate the viruses, the egg-based preparation is purified in several steps by means of filtration and addition of buffer solutions. The CIP system from Bosch is used for cleaning the pharmaceutical purification equipment, which ranges from the harvesting system to a variety of filtration and separation systems to the process tank with finished active substance concentrate, and at the same time thermally inactivates the wastewater.
Operator Safety is the Highest Priority
Handling of live viruses poses a threat to the staff and requires high equipment security measures. Consequently, the CIP system and all system modules are designed according to biosafety level 3 (BSL 3). To keep viruses from escaping to the outside, Bosch has designed a completely closed system with fixed piping and a hermetic CIP pressure vessel. The pumps for supply and return of rinsing media are equipped with double mechanical seals and sealing liquid (pure steam condensate) in the space between the seals, ensuring that no contaminated cleaning media escapes into the environment.
Easy Operation with the Touch Panel
The system in compact skid design provides essential advantages to the user: Due to its modular construction, it can be transported easily, as well as set up and connected to the media supply of the building quickly. If production is moved to another location, the system can be reinstalled at the new site without difficulty. The touch control panel with a user-friendly menu enables simple parameterisation of the cleaning programme. All components and parts coming in contact with the media are made of stainless steel and fitted with a high-quality surface. Hence the system can clean itself without residue between applications, and can be sanitised with water for injection (WFI) at a temperature of 125 ºC.
As a satellite system, the CIP system is designed for cleaning of various process systems on a rotating basis, as well as for cleaning of tubing or loops. With a volume of 800 L, the CIP tank has the necessary size to clean process tanks with a useable volume of approximately 2000 L. Sodium hydroxide, which is prepared in a separate tank, is used as the cleaning medium.
Related News
-
News Pharmapack Awards 2024 Patient-Centric Design Award Winner – Dr Ferrer BioPharma
The 2024 Pharmapack Awards celebrated the best in innovation and design for the pharmaceutical packaging and drug delivery industry on January 24, 2024. -
News Women in Pharma: Minding the Gap at Pharmapack 2024
2024 marks the first year Pharmapack will host a Diversity track dedicated to bridging the gap within the pharmaceutical packaging and drug delivery sector. The track includes a panel discussion on 'Enabling Diversity in the Workplace,' focused... -
News Pharmapack Awards 2024 - Celebrating Packaging and Drug Delivery Innovation
The 2024 Pharmapack Innovation Awards ceremony celebrated the best in pharmaceutical packaging and drug delivery innovation at all levels. The awards were held on January 24, 2024 at the Paris Expo Porte de Versailles. -
News Pharmapack 2024 - From the Floor
Paris once again welcomes Europe’s leading trade show in pharmaceutical packaging and drug delivery innovation. Join our content team as Pharmapack 2024 opens its doors to leading experts and innovators in pharmaceutical packaging and drug delive... -
News CPHI Barcelona 2023: Partnering for Success – Managing Outsourcing Relationships to Optimise Manufacturing Operations
During CPHI Barcelona 2023, insightful content sessions offered attendees the chance to explore trending topics with expert speakers and panellists. Here, we summarise what the pharma industry and supply chain are talking about the most. -
News CPHI Barcelona 2023: Loading Potential – Artificial Intelligence for Pharma Manufacturing
During CPHI Barcelona 2023, insightful content sessions offered attendees the chance to explore trending topics with expert speakers and panellists. Here, we summarise what the pharma industry and supply chain are talking about the most. -
News Pharmaceutical industry supports COP28 health stance in joint statement
As COP28 takes place over this week in Dubai, UAE, several bodies in the pharmaceutical and health industries have come together to announce support of key movements in sustainability in the sector, and to recognise sustainability as a health issue.&nb... -
News CPHI Podcast Series: Start-ups take centre stage at CPHI Barcelona
The first episode of the CPHI Podcast Series since we attended CPHI Barcelona in October covers the Start-up market at the event, with expert Matthew Wise joining Editor Lucy Chard to discuss the event.
Position your company at the heart of the global Pharma industry with a CPHI Online membership
-
Your products and solutions visible to thousands of visitors within the largest Pharma marketplace
-
Generate high-quality, engaged leads for your business, all year round
-
Promote your business as the industry’s thought-leader by hosting your reports, brochures and videos within your profile
-
Your company’s profile boosted at all participating CPHI events
-
An easy-to-use platform with a detailed dashboard showing your leads and performance