CPhI Online

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Catalent's new launch improves titers and cell-specific productivity

13 Nov 2019

GPEx Boost has been shown to improve titers up to four-fold.

Catalent has launched its next-generation cell line development technology, GPEx Boost. The technology enhances Catalent’s proven GPEx expression platform through multiple improvements, including utilization of a glutamine synthase (GS) knock-out Chinese hamster ovary (CHO) cell line. The combination of technology and platform enhancements has resulted in improved ability of cells to produce high titers and increase specific productivities of a protein of interest.

GPEx Boost has been shown to improve titers up to four-fold, potentially to 10 g/L for standard monoclonal antibodies, while maintaining the stability benefits offered by the traditional GPEx platform. In addition, benefits have been observed in cell growth and viability. Developmental timelines for projects can be shortened and made more efficient by combining this new platform with the rapid screening capabilities of Berkeley Lights’ Beacon optofluidic platform, and ambr automated micro bioreactors.

“GPEx Boost technology builds on the proven GPEx platform to enable significantly higher productivity and stability for even the most difficult-to-express proteins,” commented Michael Riley, President, USA Region of Catalent Biologics. “This new proprietary platform can also be combined with other state-of-the-art technology, such as the Beacon system, to provide a unique development tool for our customers.”