Cerbios-Pharma SA

About Cerbios-Pharma SA

Cerbios is a privately held company located in Lugano, Switzerland,  specialized in  manufacturing Pharma Products and in offering CDMO services

Cerbios is a global leading supplier of a portfolio of Generic APIs primarily used in Oncology and for the treatment of Respiratory and Dermatological disorders. Cerbios has additionally a 40 years experience in the probiotics field: the portfolio include  a FDF based on proprietary strain SF68® for treatment of diarrhea and dysbiosis by antibiotics and two new Food Supplements for the management of ACNE & Seborrheic dermatitis and to boost immune response 

Cerbios is also the ideal CDMO partner from clinical to commercial supply of API, HPAPIs, Payloads, ADCs, live Biotherapeutics, Proteins and Antibodies. Services offered include Process & Analytical Development, Scale-up and Clinical Supply, Industrial Validation, Commercial Supply, Full CMC Regulatory Support. Proveo (TM), is a Cerbios division recently created to provide end-to-end development and manufacturing services for ADCs. 

  • CH
  • 2015
    On CPhI since
  • 100 - 249
    Employees
Manufacturer/Innovator
Contact info

Products from Cerbios-Pharma SA

  • Calcium Folinate

    Product Calcium Folinate

    Calcium Folinate / Leucovorin Calcium EP/USP/IP is a Reduced Folate also used for colon-rectal cancer treatment and rescue remedy with some oncological therapies.

    USE
    The API Calcium Folinate has been manufacturing by Cerbios  for more than 30 years and is commercialized worldwide.
    Calcium Folinate is mainly used in the treatment of colon rectal cancer in combination with 5-fluorouracil (5-FU) and Oxaliplatin (FOLFOX regimen) or in combination with 5-FU and Irinotecan (FOLFIRI regimen).

    Additionally, it is administered as rescue therapy to reduce toxic effects after high dose therapy with methotrexate in the treatment of some neoplastic diseases, rheumatoid arthritis and severe psoriasis. Calcium Folinate is also given to treat anemia caused by folate deficiencies.

  • Calcipotriol Anhydrous

    Product Calcipotriol Anhydrous

    Calcipotriol / Calcipotriene Anhydrous is a HPAI Vitamin D Derivative used for the treatment of moderate plaque psoriasis.

    Much work has been  devoted to the development of Vitamin D analogues in the past decades. The key issue has been  the identification of the best candidates showing the desired cell differentiating and immunomodulating activity, while strongly avoiding the undesirable reduction of hypercalcemic activity.
    Calcipotriol Anhydrous was the first Vitamin D analogue HPAI on the market, used in the treatment of psoriasis as a cream and ointment. It is available as scalp lotion, cream or ointment.

    Combined with a potent steroid (Betamethasone), it is more effective and better tolerated. New innovative formulations are under development.

    USE
    A great deal of activity was devoted during the last years in order to develop analogues of Vitamin D showing the desired cell differenciating and immunomodulating activity, but with strongly reduced hypercalcemic activity *repetition.

    Synergies  with other treatments, like PUVA, UVB and ciclosporin have  been reported in some studies.

  • Calcipotriol Monohydrate

    Product Calcipotriol Monohydrate

    Calcipotriol / Calcipotriene Monohydrate is an HPAI Vitamin D Derivative used for the treatment of plaque psoriasis, also in combination with steroids.

    Calcipotriol Monohydrate is a synthetic Vitamin D3 derivative, prescribed for once or twice-daily use in the treatment of moderate plaque psoriasis. It is commonly recommended for topical dermatological application. The combination of Calcipotriol Monohydrate with a corticosteroid improves efficacy and decreases skin irritation.

    USE
    During the last years a great deal of activity has been devoted  to developing analogues of Vitamin D which show the desired cell differentiating and immunomodulating activity, but with strongly reduced hypercalcemic activity.

    Calcipotriol was the first Vitamin D analogue on the market and is licensed for once/twice-daily use in the treatment of moderate plaque psoriasis. Calcipotriol Monohydrate, a synthetic Vitamin D3 derivative, is commonly used for topical dermatological use as well. The Combination of Calcipotriol Monohydrate with a corticosteroid improves efficacy and decreases skin irritation.

  • Calcium Levomefolate

    Product Calcium Levomefolate

    Active Pharmaceutical Ingredient (6S)-5-Methyl-tetrahydrofolic Acid Calcium Salt is used as a food supplement for folate deficiency and also in cases of depression disorders.

    6S)-5-Methyl-tetrahydrofolic Acid Calcium Salt is the isomerically pure form of 5-Methyl-tetrahydrofolic, Acid Calcium Salt. It is commonly used as nutritional supplement in case of folate deficiency, but also subscribed for some types of depressive disorders.

    USE
    (6S)-5-Methyl-tetrahydrofolic Acid can be used as nutritional supplement in cases of folate deficiency which typically occur in a range of different situations like inadequate nutrition, absorption or utilization or increased requirements (pregnancy, lactation, malignancy) and whose possible consequences can be: birth defects (i.e. “spina bifida”), megaloblasticanemia, some types of depression.

  • Levomefolate Free Acid

    Product Levomefolate Free Acid

    Active Pharmaceutical Ingredients, (API), crystalline (6S)-5-Methyl-tetrahydrofolic Acid is used as a food supplement for folate deficiency and also in cases of depression disorders or as alternative of the Calcium Salt.
    (6S)-5-Methyl-tetrahydrofolic Acid is the isomerically pure form of 5-Methyl-tetrahydrofolic Acid. In analogy with the corresponding Calcium sal, it can be used as nutritional supplement in case of folate deficiency, but also for treating some types of depressive disorders.

    USE
    (6S)-5-Methyl-tetrahydrofolic Acid  can be used as nutritional supplement in cases of folate deficiency which typically occur in a range of  different situations like inadequate nutrition, absorption or utilization or increased requirements (pregnancy, lactation, malignancy) and whose possible consequences can be: birth defects (i.e. “spina bifida”), megaloblasticanemia, some types of depression.

  • Tiotropium Bromide

    Product Tiotropium Bromide

    Tiotropium Bromide is a long-acting muscarinic antagonist (LAMA) approved for use in chronic obstructive pulmonary disease (COPD).
    Tiotropium Bromide is a long acting antagonist of muscarinic receptors, which is often referred to as an anticholinergic.
    It is available on the market and formulated as dry powder and soft mist inhaler devices.
    It is indicated for the long-term treatment of COPD-associated bronchospasm and for the management of exacerbations. Tiotropium was the first LAMA on the market, making it the gold-standard monotherapy in COPD. It is also approved for use in asthma.

    USE
    Tiotropium exhibits its pharmacological effects through the inhibition of M3–receptors in the smooth muscle whch lead to bronchodilation. The competitive and reversible nature of this antagonism is shown to last longer than 24 hours. Bronchodilation following the inhalation of tiotropium is predominantly a site–specific effect.
    Tiotropium is mainly used for long-term treatment of reversible bronchospasms associated with COPD, including chronic bronchitis and emphysema. Tiotropium, as well as other LAMAs, are also recommended for maintenance monotherapy in patients with moderate to severe COPD who have persistent symptoms which has not been relieved by a selective, short-acting inhaled β2-adrenergic agonist therapy.

    Oral inhalation using special devices that deliver the powdered drug from inside the capsules or a solution containing tiotropium is administered. Capsules should not be used orally, as the favourable effects on the lungs will not be obtained.
    Products covered by valid patents in any country are not offered or supplied to these countries for commercial purpose.
    Only the use for research and development is allowed.

  • Calcitriol

    Product Calcitriol

    Calcitriol is a HPAI Vitamin D3 Derivative prescribed for osteoporosis, hyperparathyroidism, renal osteodistrophy and psoriasis.

    Calcitriol is the hormonally active metabolite of Vitamin D and is normally prescribed in cases of: calcium malabsorption, hypoparathyroidism, rickets, osteoporosis, renal osteodistrophy and osteomalacia.
    It also carries out other functions such as cell differentiating and immune modulating activity. It is therefore recommended for the treatment of hyperparatyroidism, psoriasis, some autoimmune diseases and certain cancer types.

    USE
    Vitamin D3 is a prohormone produced in skin through ultraviolet irradiation of 7-dehydrocholesterol. It is biologically inert and must be metabolized to 25-hydroxyvitamin D3 in the liver and then to 1a,25-dihydroxyvitamin D3 (=Calcitriol) in the kidney in order to exert its function. Calcitriol carries out many functions: calcium absorption, phosphate absorption in the intestine, calcium mobilization in bone and calcium reabsorption in the kidney.

    Calcitriol is typically used for calcium malabsorption, rickets, osteoporosis, renal osteodistrophy and osteomalacia.
    Calcitriol exerts also other functions such as cell differentiating and immunomodulating activity. Therefore Calcitriol is also prescribed for treating hyperparatyroidism, psoriasis, some autoimmune diseases and certain types of cancer (with strict dosage control).

  • Calcium Levofolinate

    Product Calcium Levofolinate

    (6S)-Calcium Folinate / Calcium Levofolinate EP is the active Isomer of Calcium Folinate, commonly used to reduce the toxic effects of some oncological therapies.

    6S)-Calcium Folinate is the isomerically pure form of the (6RS)-mixture. It is commonly used to reduce the toxic effects of methotrexate and some other oncological therapies. It is also subscribed to treat anaemia caused by folate deficiencies and prescribed in synergistic combination with the chemotherapy agent 5-Fluorouracil in treating colon cancer (FOLFOX or FOLFIRI regimen).

    USE
    (6S)-Calcium Folinate is the isomerically pure form of the (6RS)-mixture. It is the biologically active form, having the (6S)-configuration at the C6 atom, which is typical for the “natural” folate pool.

    The product is commonly used to reduce the toxic effects of methotrexate and certain other medicines (folic acid antagonists).
    For information related to its use, refer to the product sheet on Calcium Folinate and to the chapter on general Reduced Folates.

  • Calcium Mefolinate

    Product Calcium Mefolinate

    Active Pharmaceutical Ingredient, (6RS)-N5-Methyl-tetrahydrofolic Acid Calcium Salt (5-MeTHF), is suitable for oncological and nutritional use. Can also be subscribed for treatment of depressive disorders.

    A characteristic property which distinguishes N5-Methyl-tetrahydrofolic Acid Calcium Salt from other Reduced Folates is that it can cross the brain blood barrier. This has significance for example, in cases of treatment for depression. It is also subscribed for both oncological and nutritional use as other Reduced Folates.

    USE
    5-Methyl-tetrahydrofolic Acid Calcium Salt (5-MeTHF) is prescribed for anemic indications. In particular, it is recommended in cases of Folate deficiencies, especially for the health of the elderly, children and women. For anemic symptoms Oral Dosage Forms are usually administered.
    5-Methyl-tetrahydrofolic Acid Calcium Salt (5-MeTHF), is thus suitable for oncological and nutritional use.
    For more details on the use of 5-Methyl-Tetrahydrofolic Acid in the oncological and nutritional field, see Reduced Folates chapter.
    A characteristic property which distinguishes 5-Methyl-Tetrahydrofolic Acid from other reduced folates is that it can cross the brain blood barrier. This has implications, for example, in cases of treatment for depression as shown in the chapter on general Reduced Folates.

  • Cernivet® LBC ME20 plus

    Product Cernivet® LBC ME20 plus

    The probiotic feed additive Cernivet® LBC ME20 plus is the best microencapsulated form of our product range which can withstand aggressive pelleting processes.
    The probiotic feed additive Cernivet® LBC ME20 plus can withstand pelleting processes with a total energy input up to 40 kWh/ton. It is registered in the EU for application in calves, chickens for fattening and swine. This product is suitable for all types of feeding stuffs.

    USE
    Cernivet® LBC ME20 plus is a pelletable microbial feed additive for the stabilization of the intestinal microflora, based on the probiotic active ingredient E. faecium SF68® (strain deposit E. faecium NCIMB 10415).

  • Doxercalciferol

    Product Doxercalciferol

    Doxercalciferol is a synthetic Vitamin D2 Analog which regulates blood calcium at levels required for essential body functions. It acts on bone cells, (osteoblasts), to stimulate skeletal growth and on the parathyroid glands to suppress PTH synthesis and secretion. In patients with renal failure, it prevents the development of metabolic bone disease.

    USE
    Doxercalciferol is a synthetic Vitamin D2 analog undergoing metabolic activation in vivo to form 1α,25-dihydroxyvitamin D2 (1α,25-(OH)2D2), a naturally occurring, biologically active form of Vitamin D2.  This one regulates blood calcium at levels required for essential body functions. The biologically active Vitamin D metabolites control the intestinal absorption of dietary calcium, the tubular reabsorption of calcium by the kidney and, in conjunction with parathyroid hormone (PTH), the mobilization of calcium from the skeleton. They act directly on bone cells to stimulate skeletal growth, and on the parathyroid glands to suppress PTH synthesis and secretion. In uremic patients, deficient production of biologically active vitamin D metabolites (due to lack of or insufficient 25hydroxyvitamin D-1-alpha-hydroxylase activity) leads to secondary hyperparathyroidism, which contributes to the development of metabolic bone disease in patients with renal failure.

  • Pharmaceutical probiotics based on SF68®

    Product Pharmaceutical probiotics based on SF68®

    Pharmaceutical probiotics based on SF68® have a long history of safe use and proven efficacy in the prevention and treatment of intestinal disorders.

    Cerbios has long-term customers receiving products based on Enterococcus faecium SF68® (SF68®) in different forms of standardized active ingredients, intermediates and finished products, such as hard gelatin capsules in glass bottles. Licensing opportunities for several markets are available.

    USE
    SF68® is considered one of the best characterized probiotic active ingredients for the prevention and treatment of intestinal disorders. The pharmacological properties and safety profile of SF68® have been extensively studied. The efficacy of SF68® has been confirmed in many double blind clinical trials.

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