ChemoCentryx Initiates CCX168 Phase II Trial
The randomised double-blind placebo-controlled trial will evaluate the safety and tolerability of CCX168 in patients with ANCA-associated renal vasculitis.
US clinical-stage biopharmaceutical firm ChemoCentryx has launched a Phase II clinical trial for CCX168, an orally-administered small molecule for the treatment of anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV).
CCX168 specifically targets the C5a receptor (C5aR), a potent pro-inflammatory mediator responsible for AAV, as well as several other autoimmune diseases.
The randomised double-blind placebo-controlled trial will evaluate the safety and tolerability of CCX168 in patients with ANCA-associated renal vasculitis, while assessing the potential for reducing or eliminating the use of corticosteroids in the patients.
ChemoCentryx president and CEO Thomas Schall said the company's drug can
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