Chlorotoxin

Chlorotoxin
Product Description

Chlorotoxin is a 36-amino acid peptide found in the venom of the deathstalker scorpion (Leiurus quinquestriatus) which blocks small-conductance chloride channels. The fact that chlorotoxin binds preferentially to glioma cells has allowed the development of new methods for the treatment and diagnosis of several types of cancer. TM-601 which is the synthetic version of chlorotoxin is under phase II clinical trial. Iodine-131-TM-601 is used to treat malignant glioma. TM-601 is also a candidate for targeting gliomas because it crosses blood-brain and tissue barriers and binds to malignant brain tumor cells without affecting healthy tissue. 

CBL

  • GR
  • 2019
    On CPHI since
Specifications
  • CAS Registry Number
    163515-35-3

CBL

  • GR
  • 2019
    On CPHI since

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CBL resources (1)

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    CBL, the “Peptide Innovators” was recently inspected both by the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA). Approvals were received from both agencies for the API manufacturing of octreotide.