This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC's registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

28 Apr 2011

Hepatitis B Virus Reemerges with Long-term Nucleoside Analog Treatment

Results showed that during a mean follow-up of 38 months, 39 (26 percent) of patients had at least one VBT, and upon retesting, 38 percent of these patients did not have a VBT and 10 (38 percent) had no evidence of genotypic resistance.

A rebound of the Hepatitis B virus is common in patients receiving nucleoside analogs for chronic hepatitis B, according to a study from U-M hepatologists. But nearly 40% of the rebounds or virological breakthroughs (VBTs) were not related to antiviral drug resistance.


"This study underscores the need for patients to take their medicines regularly to derive optimal response," says lead author Anna S. Lok, M.D., professor of internal medicine in the University of Michigan Medical School's Division of Gastroenterology.


"These results emphasize that there is a danger of misdiagnosis of drug resistance and unnecessary modifications to treatment regimen when it could be patients not adhering to their drug regimen."

Related News