This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC's registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

News
12 Nov 2021

Hoth Therapeutics and WuXi strike API and drug product deal for cancer therapeutic

WuXi will use its new modality platform to provide an end-to-end solution for oligonucleotide peptide

China's WuXi STA has signed two contracts with Hoth Therapeutics, a clinical-stage biopharmaceutical company, for the process development and manufacturing of the API and formulation of drug product for the continued development and commercialisation of HT-KIT.

HT-KIT is Hoth's a new molecular entity (NME) morpholino oligonucleotide therapy in development for targeting mast cell-derived cancers and anaphylaxis.

Through the agreements, the two companies expect to accelerate the development of this new modality therapy with rapid and efficient PMO manufacturing scale-up from feasibility batches to GMP material.

WuXi STA will utilise its integrated CRDMO (contract research development and manufacturing organisation) new modality platform to provide an end-to-end solution for oligonucleotide peptide as well as their conjugates for both API and formulation under one roof.

The company has already begun the HT-KIT API process development for manufacturing and expects to yield small-scale material during the first quarter of 2022.

API manuacturing will be immediately followed by initiation of formulation development for HT-KIT, which Hoth intends to develop as a parenteral formulation for injection.

Hoth has said it intends to pursue a pre-IND meeting with the FDA after completion of formulation development.

Mentioned Companies
WuXi STA
View company profile
STA Pharmaceutical
View company profile

Related News