Hovione collaborates with Kiel University on high dose inhalation delivery

The collaborative project will develop and explore new formulation possibilities using softpellets and nanocrystals for high dose administration via dry powder inhalation using antibiotics such as clarithromycin and rifampicin as model drugs.

“We are excited to collaborate with world-leading researchers in the field of inhaled drug delivery and very pleased they decided to work with our Large Dose DPI technologies TwinMax and 8Shot. We are observing new drugs to treat cystic fibrosis, pulmonary arterial hypertension, idiopathic pulmonary fibrosis or lung infections are requiring delivery of large lung doses, often within the range of 50 to 150 mg”, said João Ventura Fernandes, Hovione Technology’s Director of Technology Development and Licensing.

“If we want to deliver high doses of drug to the lung, it is not only about an innovative formulation, but we also need an effective delivery device”, said Professor Regina Scherließ, Director of Kiel University’s Institute of Pharmacy, working for 15 years in the area of inhaled drug delivery. “Thus, we are very happy to include Hovione Technology’s Large Dose DPIs into our formulation research.”

The collaborative project will develop and explore new formulation possibilities using softpellets and nanocrystals for high dose administration via dry powder inhalation using antibiotics such as clarithromycin and rifampicin as model drugs. Hovione Technology’s TwinMax and 8Shot inhalation devices, capable of delivering high doses of powder formulations, will be used throughout formulation development and optimization.

About Large Dose DPIs

Hovione Technology’s TwinMax and 8Shot dry powder inhalers are designed to enable safe and effective delivery of large doses to the lung. Featuring patent-granted inhaler technology compatible with drug doses up to 400 mg, delivered conveniently to patients from multiple inhalations, they are suitable for inhaled delivery of antibiotics, peptides, anti-virals, vaccines, pain or rescue treatments.