The HSA LAB equipment belongs to a family
of non-destructive analyzers intended for monitoring headspace gas compositions
in optically transparent and sealed containers. It employs a non-invasive
laser-based technique for monitoring the headspace levels of gases such as
oxygen, carbon dioxide and moisture content. HSA LAB is a benchtop system that can be used throughout the entire sterile parenteral product lifecycle, from early stages of development to laboratory applications to in-process control of headspace conditions and monitoring the quality and stability of production.
Headspace Analysis “HSA” is based on the
Tunable Diode Laser Absorption Spectroscopy (TDLAS) method which accurately
detects and quantifies gaseous concentration levels. A diode laser beam is transmitted through the
container in the region above the product and below the cap/closure (headspace);
laser beam is then received by a detector. The amount of light absorbed while
crossing the headspace is measured and related to the target gas concentration.
The laser beam
wavelength is tuned around the absorption frequency of the target gas to be
monitored.
The HSA technology allows
to perform a quick and accurate monitoring of headspace gas, by determining the
nitrogen purging efficiency and by ensuring container closure integrity; it is
applicable to sterile products that are packaged under modified atmospheric
conditions or under a certain level of negative pressure.
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