CPhI Online is the largest global marketplace in the pharma ingredients industry
a leading biotech and industrial player in the development and production of
innovative, pharmaceutical-grade biopolymers that are used by leading
pharmaceutical and medical device companies to transform the lives of millions
of patients in multiple therapeutic areas such as ophthalmology, dermatology,
medical aesthetics, rheumatology, and urology.
A pioneer in the bioproduction of hyaluronic acid, HTL has developed and refined its innovative functional biopolymer platform that has enabled it to produce "customised", pharmaceutical grade products for customers worldwide for over 25 years.
HTL is at the forefront of innovation in the biopolymer industry to meet tomorrow's medical needs by creating new types of biopolymers and chemical modifications, while exploring the untapped potential of biopolymers in innovative applications such as bioprinting or drug delivery.
HTL conducts its production activities in fully compliant cGMP facilities.
To find out more about HTL: www.htlbiotech.com
Products from HTL
Hyaluronic acid, also known as Hyaluronan, is a biopolymer that is naturally present in the human body. It has been used for many years as a raw material or ingredient for medical products in various fields including ophthalmology, orthopaedics and dermatology.
HTL produces injectable grade Hyaluronic Acid for premium medical applications. It is a product of non-animal, natural origin, obtained in HTL’s state-of-the-art manufacturing facilities in France.
HTL has a long history of providing the best quality on the market, in terms of purity level, batch to batch consistency and stability. HTL provides the widest range of options, having the unique ability to produce hyaluronan from a very low to a very high molecular weight (from 8kDa to 4.5MDa, intrinsic viscosity up to 3.8m3/kg). HTL can produce hyaluronan in fiber form.
HTL can supply tailor-made functionalized derivatives of hyaluronic acid.
While most Chondroitin sulfate on the market is of animal origin, HTL is developing a new source of Chondroitin of non-animal origin with the use of fermentation. Chondroitin sulfate can then be obtained by sulfation.
Characteristics and benefits of Chondroitin by fermentation:
- absence of animal traces and prion contamination
- helps protect endangered animal species
- access to a Chondroitin with higher molecular weight, which opens up the potential for new applications
Today’s applications: rheumatology, ophthalmology.
Potential applications: tissue engineering, oncology, anti-inflammatory and anti-viral potential
HTL is developing Heparosan, a promising raw material for the design of innovative medical devices. Under license, HTL will be the sole producer of medical grade, high molecular weight Heparosan by fermentation (20 kDa to 2MDa). Safe for use in humans, Heparosan is an endogenous GlycosAminoGlycan with a structure very close to that of hyaluronan, but it cannot be hydrolyzed by hyaluronidase enzymes. HTL is your partner for the development of tailor-made functionalized derivatives such as Heparosan sulfate.
The physico-chemical and biological characteristics of Heparosan will enable to produce a variety of superior biomaterials, gels and scaffolds, with a potentially increased lifetime and water retention capability compared to existing biomaterials.
Potential applications: ophthalmology, orthopedics, aesthetics, dermatology, coating of medical devices, tissue engineering, drug delivery systems development.
HTL offers the tailor-made development of functionalized derivatives of Glycosaminoglycans, such as modified Hyaluronic Acid, Heparosan and Chondroitin. Developing new functionalities by chemical modification allows the optimization of existing uses of these biopolymers, but also opens opportunities for new medical applications.
Typical chemical modifications: Hydrazidation, epoxy grafting, sulfation, silylation, deacetylation, alkylation
New functionalities thanks to chemical modification:
Optimizing physico-chemical properties
- Viscodynamic properties
- Solubility in biological media
- Extended half-life
- Improved resistance to oxidative stress and catabolic enzymes
- Tissue adhesion
- Tissue integration
- Tissue improvement
- Targeted delivery
HTL is a French biotechnology company and industrial player that has become a world leader in the development and production of pharmaceutical-grade biopolymers. Thanks to this new investment of 50 million euros, HTL will more than double its production capacity, allowing it to accelerate its international development and become the world's largest producer of pharmaceutical-grade hyaluronic acid. Biopolymers produced by this unit will enable an increasing number of leading companies in the pharmaceutical and medical devices sectors to offer innovative therapeutic solutions to their patients worldwide.
HYALURONIC ACID & BIOPOLYMERS FOR PREMIUM MEDICAL PRODUCTS
All over the world, men and women are living longer. They aspire to better health, greater well-being, and living life to its fullest, whatever their age. Since its creation, HTL’s mission has been to invent innovative solutions to meet the health challenges of the future. And because the best remedies are those that reside in us, we have focused our research on the biopolymers naturally existing in the human body...
In December 2020, HTL participated in the financing of a cell sorting equipment for the French Research team Bioscar (INSERM 1132 unit, Paris Lariboisière).Bioscar is dedicated to the pathophysiology of bone and cartilage diseases. The team seeks to identify the molecules at the source of disease mechanisms, potentially in relationship with long COVID.
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