Hydroxypropyl Betadex can improve the physicochemical properties of β - carotene

β-carotene (β-car) is one of the most important carotenoids, which plays an important role in health care and disease prevention. Because β - car is insoluble in water and slightly soluble in oil and is sensitive to light and air, it is easy to be oxidized and reduce its biological activity, so it is limited in practical application. At present, the main form of beta carotene is divided into beta carotene oil suspension, beta carotene water dispersible dry powder and beta carotene emulsion, all of which rely on adding antioxidants to improve its stability. The preservation conditions of emulsion formulations are severe, and the storage period is shorter than that of dry powder, and the cost is lower. The water dispersible dry powder has a long storage period, but its stability is not ideal, and the efficiency and yield of microencapsulation process are not ideal because of the poor coordination between carbohydrate dextrin and gelatin compatible with protein wall material. Therefore, the use of cyclodextrin (CD) inclusion technology to improve the stability and solubility of β - car has attracted people's attention.

Hydroxypropyl Betadex (HP-β-CD,Hydroxypropyl beta cyclodextrin) is a derivative of beta cyclodextrin (β - CD), which has the advantages of β - CD and good water solubility at room temperature. β - car is a fat soluble compound. After being made into cyclodextrin inclusion complex, it presents new phase characteristics, and its physical and chemical properties have been significantly improved, and its solubility in water is significantly improved, from water-insoluble to water-soluble The inclusion rate, purity and stability of β - car were improved after inclusion with Hydroxypropyl Betadex.

Shandong Binzhou Zhiyuan Biological Technology Co., Ltd. has made deep research on the physical and chemical properties, preparation process, stability, pharmacology, toxicology, teratogenicity, mutagenicity, carcinogenesis, hemolysis and irritation of Hydroxypropyl Betadex. The CDE registration number f20209990366 has been activated. For more information, please refer to Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. E-mail: [email protected].