INNOVATIVE CONTINUOUS PELLETISING TECHNOLOGIES
Glatt Pharmaceutical Services, the CDMO division of Glatt offers its formulation and product development services using innovative direct pelletizing technologies to support you with tailored solutions. Some of the Technologies are described below.
MicroPx™ Technology
The MicroPx™ Technology is a continuous fluid bed process. For the pelletisation no starting cores are required. Typically, all formulation components like the API, pharmaceutical binder(s) and other functional ingredients are contained in a liquid which is fed into the MicroPx™ process via spray guns; the spraying liquid can be a solution, suspension, emulsion or the like. Outstanding product characteristics of MicroPx™ pellets:
- spherical and smooth pellet surfaces = ideal for coating applications like taste masking, controlled release coating etc.
- high density / low porosity of pellets
- high drug loading: typically 95%
- low attrition and friability
- dust free surfaces
- mean particle size range: 100 – 500 µm
- narrow particle size distribution (e.g. > 90% between 100 –300 µm without sieving)
- inclusion of bioavailability enhancers, controlled release polymers etc.
ProCell™ Technology
The Glatt ProCell™ Technology is a spouted-bed type pelletizing process for the preparation of very high concentrated pellet-shaped particles; ideally, no additional excipients may be required for the formation of ProCell™ particles – in this case particles consisting of pure API are reached. Outstanding product characteristics of ProCell™ granules and pellets:
- very high drug load up to 100%
- mean particle size range from 50 – 1500 µm
- narrow particle size distribution
- high density / low porosity of particles
- low attrition and friability
- particularily suitable for processing of products with inherent stickiness
The innovative fluid bed pelletising technologies – MicroPx™, ProCell™ and CPS™ - complement the actual capabilities of GLATT fluid bed technology. In addition to established pelletising approaches new options are made available which offer additional solutions to the classical standard Technologies.
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