Legacy plans for lyophilisation boom

14 May 2019

The increase in biologics is driving the growth in demand for lyophilization in vials.

Legacy Pharmaceuticals, a global contract manufacturer of sterile/aseptic pharmaceutical products in ampoules and vials, has announced their long-term expansion strategy to address the global growth in demand for lyophilization in vials.

Legacy plans for lyophilisation boom

The 5-year plan builds on Legacy’s existing core fill finish competencies in lyophilization, and liquid and powder vials. As a first step Legacy has already started a project to add customized lyophilization in vials for an ongoing customer project, with an anticipated start date of mid-2020.

Lyophilization in vials is a trend in the industry that continues to grow due to the increase of biologicals. Already the share of injectable/infusible lyophilized drugs approved has risen from 11.9% in 1999 to over 50% and is still predicted to increase. Main product types include cell and cell-based therapies, small molecule drugs, diagnostics and biologics, including peptides, recombinant proteins and vaccines.

“By 2020, global pharma companies estimate lyophilized drugs will represent 30-40% of their pipeline. However, the manufacturing capacity our industry needs does not exist at the moment, and it cannot be built overnight. Decisions need to be taken now, which is why we are announcing this expansion strategy and committing to increasing our capacity. Legacy is planning to build a lyophilization suite with closed RABS filling line technology, two to three freeze dryers up to 30-m2 scale each and automated load and unloading systems. We estimate a construction timeframe in the order of 24-30 months. We are now looking to open discussions with existing and new customers interested to retain capacity in this strategic project,“ commented Mike Danzi, CEO of Legacy Pharmaceuticals.

Read More

Related news

Legacy ramps up preparations for new Russian track and trace sterilisation regulations

Legacy ramps up preparations for new Russian track and trace sterilisation regulations

18 Jul 2019

Company to install new inspection cameras with higher resolution to ensure readability of more complex codes demanded by the Russian mandated crypto coding.

Read more 
Combination technique improves polysaccharide characterization

Combination technique improves polysaccharide characterization

17 Jul 2019

The AF4-MALS-RI method makes possible the accurate determination of molecular weight distribution of polysaccharide macromolecules.

Read more 
Lubrizol integrates personal, home and health care divisions

Lubrizol integrates personal, home and health care divisions

16 Jul 2019

The new brand - Lubrizol Life Sciences - aims to maximize client speed-to-market, providing enhanced solutions.

Read more 
Bosch finds buyers for its packaging machinery business

Bosch finds buyers for its packaging machinery business

16 Jul 2019

CVC Capital Partners to " take the business forward in the years ahead, and to make it even more competitive".

Read more 
New state-of-the-art cleanroom boosts production of anticancer drugs

New state-of-the-art cleanroom boosts production of anticancer drugs

15 Jul 2019

The GMP facility has been specifically designed to deliver the next generation of anticancer blockbuster ADC drugs for patients globally.

Read more 
Colorcon chooses the Netherlands for new starch manufacturing plant

Colorcon chooses the Netherlands for new starch manufacturing plant

12 Jul 2019

The plant will provide a secure second source of supply of Starch 1500, Pregelatinized Maize Starch.

Read more 
GSK opens new continuous manufacturing facilities in Singapore

GSK opens new continuous manufacturing facilities in Singapore

11 Jul 2019

Opening of continuous manufacturing facilities and expansion of production building will boost capabilities to accelerate the supply of new breakthrough medicines to patients globally.

Read more 
Eisai collaborates with University of Dundee on cancer drug discovery

Eisai collaborates with University of Dundee on cancer drug discovery

10 Jul 2019

It is hoped that research into PROTACs will lead to new drug discoveries for proteins present in cancer, which are difficult to treat with conventional small molecule inhibitors.

Read more 
Onyx Scientific makes strategic investment in commercial API licence

Onyx Scientific makes strategic investment in commercial API licence

10 Jul 2019

Investment fills the growing gap in the market for manufacturers that have the niche capabilities to deliver small-scale commercial API projects.

Read more 
I Holland to share the science behind tool maintenance

I Holland to share the science behind tool maintenance

9 Jul 2019

Proper maintenance - rather than replacement - of compression tooling will improve profitability.

Read more