Lonza's new medium boosts and optimizes AAV production in insect cells23 Mar 2020
The TheraPEAK SfAAV Medium is specifically designed to support the development of safe, scalable, gene therapies.
In an effort to help biotechnology companies to fast track the development of safe gene therapies to treat a range of life-threatening conditions, Lonza has launched the first chemically defined, non-animal origin medium designed to increase Adeno Associated Virus (AAV) production in Spodoptera Fuigiperda Sf9 insect cells.
The new high-performance medium accelerates cell growth, increases productivity, and reduces process variability and costs, expediting time-to-market for safe, scalable, life-saving gene therapies.
Gene therapy holds great promise for the treatment of rare disorders and diseases, and viral vectors are commonly used to facilitate the delivery of the gene of interest into patient cells.
AAV has been established as a viral vector of choice, due to not replicating in patients, thus posing a lower health risk. Owing to their ability to be grown at high densities, the Sf9 insect cells are ideal for use as hosts for the production of large AAV quantities. To date, however, translational scientists and researchers have been challenged with the lack of a medium dedicated to AAV production in Sf9 insect cells.
The company reports that its TheraPEAK SfAAV Medium provides a cost and time-efficient solution for the production of AAV in Sf9 insect cells. Allowing for rapid cell growth, the TheraPEAK SfAAV Medium reduces processing time significantly, enabling cell infection one day earlier than similar media available on the market, and boosting laboratory performance.
Due to its chemically defined nature, the new hydrolysate free medium produces AAV that requires less purification, further decreasing the overall processing time and minimizing labour requirements. Furthermore, the TheraPEAK SfAAV Medium supports consistent cell growth throughout all phases of the culturing process, considerably reducing process variability.
As a chemically defined, non-animal origin product, the TheraPEAK SfAAV Medium is safer to use than media containing animal or human components, thereby facilitating regulatory compliance. Additionally, the medium is supplied with a US Food and Drug Administration drug master file, alleviating the relevant preparation and submission burden.
UPDATED: COVID-19 PHARMA TRACKER
3 Apr 2020
The latest coronavirus updates and developments impacting the global pharmaceutical supply chain…Read more
Chinese CDMOs legislating for the future
2 Apr 2020
The Chinese pharmaceutical CDMO sector is set for rapid expansion, thanks to major amendments to the country's Drug Administration Law that make outsourcing manufacturing easierRead more
FDA orders ranitidine withdrawal due to nitrosamine contamination risk
2 Apr 2020
US drug regulator, the Food and Drug Administration has ordered the immediate withdrawal of all prescription and over-the-counter versions of heartburn drug, ranitidine – commonly known as Zantac – after concluding certain products may present an incre...Read more
China focused on meeting international API demand amid pandemic, say officials
1 Apr 2020
China is stepping up its efforts to produce and ship active pharmaceutical ingredients (APIs), with a focus on meeting international demand, particularly for those showing potential to treat the COVID-19 disease, according to Chinese officials on Tuesd...Read more
New blood test able to detect 50 cancer types
31 Mar 2020
Study data support blood test's ability to detect 50 types of cancer and identify where in the body the cancer is located.Read more
Cambrex names Troy Player as head of early stage development and testing
31 Mar 2020
Cambrex has appointed pharma industry veteran, Troy Player, as president, early stage development and testing, the contract development and manufacturing organisation said Tuesday.Read more
CDMO Ritedose chooses ChargePoint to ensure drug substance mixing process sterility
31 Mar 2020
The Ritedose Corporation, a contract development and manufacturing organisation (CDMO) with a focus on inhalation and ophthalmic products, has partnered with ChargePoint Technology to ensure the sterility of its drug substance mixing process.Read more
EMA to only issue electronic medicines certificates during COVID-19 pandemic
30 Mar 2020
The European Medicines Agency (EMA) said Monday it will only issue electronically signed and authenticated certificates for human and veterinary medicines in place of printed ones so it can continue to provide the documents during the COVID-19 pandemic...Read more
PandemiCam — our greatest chance yet to detect, monitor and beat COVID-19?
30 Mar 2020
Joint venture between Spinview and VR Media Technology creates device that provides accurate and fast detection of infectious people with far greater clarity than any single parameter test available today.Read more
New device offers a convenient way to monitor compressed air for viable particles
30 Mar 2020
Specialist cleanroom microbiology solutions company offers the new SAS Super Pinocchio CR compressed air sampling device.Read more
Are you a supplier
Here's what we can do for you
- Generate quality leads for your business
- Stay visible for 365 days of the year
- Receive product inquiries and respond to meeting requests directly
- Improve company online presence through Search Engine Optimisation