May 2021 Study of Glucose Viral Inactivation in CHO using HTST
May 2021 Engineering in Life Sciences. Efficacy of minute virus of mice (MVM) inactivation utilizing high temperature short time (HTST) pasteurization and suitability assessment of pasteurized, concentrated glucose feeds in Chinese hamster ovary (CHO) cell expressions systems.
HTST pasteurization can provide significant levels of worst-case parvovirus clearance and provide viral risk mitigation for upstream cell culture feeds such as glucose.
There is a growing need to provide effective adventitious agent mitigation for high risk upstream cell culture raw materials used for the production of biologics.
70% of biologic products use Chinese Hamster Ovaries (CHO) for mammalian cell cultures. CHO is activated by glucose that is susceptible to viruses. Using High Temperature Short Time (HTST) has proven to virally inactivate the glucose while not degrading the material.
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