New cell culture microbioreactor system improves clone selection

2 May 2019

SSB's new generation of ambr 15 supports cell and gene therapy applications, including HEK293 for viral vector production, T-cells, iPSCs and other immune-derived cell lines.

Sartorius Stedim Biotech (SSB), a leading international partner of the biopharmaceutical industry, is introducing its new generation of ambr 15 cell culture automated microbioreactor system. The Generation 2 is the successor to the well-established ambr 15 cell culture system, proven in the industry to significantly reduce cell line development timelines and increase lab productivity. The new system offers increased flexibility and expanded capability for clone selection, media and feed optimization and early process development work.

New cell culture microbioreactor system improves clone selection
New ambr® 15 microbioreactor system offers increased flexibility and expanded capability for clone selection, media and feed optimization and early process development work.

The ambr 15 cell culture Generation 2, based on SSB’s gold-standard ambr technology, replicates laboratory-scale bioreactor performance at the microscale (10-15 mL) and controls up to 48 single-use bioreactor cultures in parallel. Its new design incorporates novel features to provide greater process flexibility, expands the system’s functionality and allows more applications to be investigated. In addition, a new ambr clone selection software, included as a one-year license, provides simplified, streamlined multivariate data analysis for faster, more consistent cell line screening and ranking.

Selection of clones, media and feeds can be performed under perfusion mimic conditions using new functionality to bleed large volumes of culture and quickly remove spent media from the ambr 15 microbioreactors. A new flexible workstation layout and an expanded tip bin capacity provide greater operator walk-away time.

Adaptation of cell lines to different media for media screening studies can be performed in ambr 15 microbioreactors using new culture passage steps and rapid vessel drain functionality. New media mixing steps automate the creation of media blends, eliminating the need to pre-mix, saving time and reducing chance of error. Clone stability studies can also be set up with serial passages performed and fully automated in the microbioreactors.

Read More

Related news

Eisai collaborates with University of Dundee on cancer drug discovery

Eisai collaborates with University of Dundee on cancer drug discovery

10 Jul 2019

It is hoped that research into PROTACs will lead to new drug discoveries for proteins present in cancer, which are difficult to treat with conventional small molecule inhibitors.

Read more 
Onyx Scientific makes strategic investment in commercial API licence

Onyx Scientific makes strategic investment in commercial API licence

10 Jul 2019

Investment fills the growing gap in the market for manufacturers that have the niche capabilities to deliver small-scale commercial API projects.

Read more 
I Holland to share the science behind tool maintenance

I Holland to share the science behind tool maintenance

9 Jul 2019

Proper maintenance - rather than replacement - of compression tooling will improve profitability.

Read more 
Catalent extends global commercial spray drying capabilities in Europe

Catalent extends global commercial spray drying capabilities in Europe

9 Jul 2019

Company's customers to have immediate access to Niro PSD2 and PSD4 spray driers, which are supported by dedicated clean area facilities for both solvent and aqueous processing of potent or non-potent drug formulations.

Read more 
Operations commence at Wasdell Group’s EU headquarters

Operations commence at Wasdell Group’s EU headquarters

8 Jul 2019

The new facility houses 11 bespoke production suites and temperature controlled high-way warehouses increases Wasdell’s capacity in clinical and commercial packaging, distribution & logistics and QP services.

Read more 
Porvair Sciences launches first Drosophila ChIP kits

Porvair Sciences launches first Drosophila ChIP kits

4 Jul 2019

Offers a single optimised Chromatrap kit with unique buffers and components for Drosophila chromatin extraction and ChIP.

Read more 
Boehringer Ingelheim expands NASH R&D pipeline with new first-in-class compound

Boehringer Ingelheim expands NASH R&D pipeline with new first-in-class compound

3 Jul 2019

Yuhan Corporation to receive up to USD 870 million in upfront and success-based development and commercialization milestones, excluding royalties.

Read more 
Fresh data on protein interactions in Alzheimer’s disease

Fresh data on protein interactions in Alzheimer’s disease

2 Jul 2019

Demonstrates the unique ability of diffusional sizing to assess protein binding in-solution and for difficult-to-study systems.

Read more 
Fujifilm Irvine Scientific to open new cell culture media manufacturing site in Europe

Fujifilm Irvine Scientific to open new cell culture media manufacturing site in Europe

2 Jul 2019

The space will support cGMP manufacturing of animal component-free, dry powder media, liquid media, and downstream bioprocessing liquids.

Read more 
Novartis bolsters ophthalmic portfolio with acquisition of Xiidra

Novartis bolsters ophthalmic portfolio with acquisition of Xiidra

1 Jul 2019

Xiidra 5% is the first and only prescription treatment approved to treat both signs and symptoms of dry eye by inhibiting inflammation caused by the disease.

Read more