Pharmaceutical Grade API Sorafenib Tosylate CAS 475207-59-1

Pharmaceutical Grade API Sorafenib Tosylate CAS 475207-59-1
Product Description

Sorafenib tosylate 475207-59-1

Product Name: Sorafenib tosylate

CAS: 475207-59-1

MF: C28H24ClF3N4O6S

MW: 637.0265696

EINECS: 641-758-8General

Description:   

Sorafenib is available in 200-mg tablets for oral administrationand is used in the treatment of RCC and colon cancer.The agent is classified as a multikinase inhibitor because ofits action on numerous kinase enzymes including thePDGF-R, Kit, and Raf. Sorafenib is 39% to 48% bioavailable and CYP3A4-mediated metabolism giveseight identified metabolites including the N-oxide, which isequally active with the parent. However, the majority of thedrug in plasma is present as the parent compound.Sorafenib is highly protein bound (99.5%). The drug iseliminated primarily in the feces (77%) with 19% appearingin the urine as glucuronides (UGT1A1) and has a eliminationhalf-life of 24 to 48 hours. The most co...

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Shandong Langnuo Pharmaceutical Co.,Ltd.

  • CN
  • 2017
    On CPHI since
Company types
Manufacturer/Innovator
View company profile
Categories
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Specifications
  • CAS Registry Number
    475207-59-1
  • Selling Points
    International Approvals/Standards; Quality Service
  • Supplied from
    China
  • Measured In
    kilogram
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Sales Markets
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Shandong Langnuo Pharmaceutical Co.,Ltd.

  • CN
  • 2017
    On CPHI since
Company types
Manufacturer/Innovator
View company profile

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