PHARMELLOSE - CROSCARMELLOSE SODIUM

Pharmellose is cross-linked carboxymethylcellulose sodium. It is a white, free flowing powder. Pharmellose is used as disintergrant in tablets, capsules and granules.  In capsules, Pharmellose suggested use level is 10-25%. 
Pharmellose as a tablet disintegrant, it may be used at concentration of up to 5%, although a use level of 2% w/w is recommended for tablets prepared by direct compression and 3% w/w, for tablets prepared by wet granulation.  Pharmellose is suitable for a variety of tablet and capsule formulations.
Pharmellose is effective in combination with both insoluble filler-binders, such as Microcrystalline Cellulose (MCC) and dicalciumphosphate and slightly soluble to soluble filler-binders such as mannitol and lactose at concentrations of 2-6%.
Pharmellose is effective when used as intra-granular or extra-granular super disintegrant, or when divided between these locations.