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Combating Coronavirus, key role of cyclodextrins in treatment and prevention

Combating Coronavirus, key role of cyclodextrins in treatment and prevention

Roquette has recently identified that its KLEPTOSE®️ hydroxypropyl beta-cyclodextrins (HPβCD) product, a functional excipient and a specialty active pharmaceutical ingredient (API), may be effective to help the joint efforts of the scientific and pharmaceutical communities working on treating and preventing new emerging viruses such as the coronavirus. HPβCD can effectively act as a safe, enabling excipient for solubility enhancement of antiviral drugs, stability improvement of therapeutic monoclonal antibodies, and as a vaccine adjuvant. KLEPTOSE®️ is a cyclodextrin, a group of structurally related natural products formed during bacterial digestion of cellulose. Cyclodextrins have indeed been shown to be effective as solubilizing and stabilizing agents in vaccines, monoclonal antibodies and oral formulations. Moreover, cyclodextrins can potentially be used for infection containment or as virucidal agents after structural modification. The company’s new position paper speaks to the potential role of cyclodextrins, such as HPβCD, in detail: “Combating Coronavirus: Key Role of Cyclodextrins in Treatment and Prevention.”