Sartorius Stedim Completes Portfolio of Salt-Tolerant Membrane Adsorbers

The small membrane volume of 0.08 ml reduces material consumption during testing and virus spiking studies to save cost during the initial development phases.

Polishing in antibody production is usually performed on quaternary ammonium (Q) membranes in flow-through mode, since the overall speed and productivity is much higher than on traditional anion-exchange columns. However, the binding capacity of Q ligands is reduced at higher conductivities, so concentrated feed streams must be diluted to adequately remove contaminants such as DNA, host cell proteins, viruses and endotoxins.

Sartobind STIC PA (primary amine) anion-exchange membrane, developed by France-based Sartorius Stedim Biotech overcomes this limitation and binds contaminants at high conductivities under high-salt conditions at up to 20 mS/cm. The salt-tolerant anion exchanger can directly process cation-exchange pools without further dilution. Buffer consumption and