SignaBlok Awarded DARPA Contract
The contract supports formulation development and in vivo proof-of-concept studies to evaluate the efficacy of TREM-1-specific SCHOOL peptides in either the free or nanoparticulate form.
Massachusetts-based biopharmaceutical company SignaBlok, Inc. has received a contract from the Defense Advanced Research Projects Agency (DARPA) to introduce company’s approach to the prevention and treatment of sepsis (blood poisoning), and to establish proof-of-concept in vivo.
SignaBlok’s approach targets an inflammation amplifier, a specific receptor called TREM-1, which has been shown to improve survival in animal models of sepsis. The company’s peptide inhibitors that are developed using a new model of cell signaling, known as the SCHOOL model, inhibit TREM-1 in a ligand-independent way and has beneficial properties.
The contract supports formulation development and in vivo proof-of-concept studies to evaluate the efficacy of TREM-1-specific SCHOOL peptides in eithe
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