Small Molecules

Small Molecules
Product Description

Our multi-patented Controlled Expansion of Supercritical Solutions (CESS®) technology enables the creation of API nanoparticles directly from solution. The process can be applied to most small molecules, with a high success rate of 80-90%.

CESS® is a bottom-up method of recrystallization that works by controlling the solubility of an API in supercritical carbon dioxide (scCO2). The use of scCO2 permits a green particle engineering process with pharmaceutical CO2 that is free from excipients and organic solvents. CESS® represents a significant improvement over previous supercritical technologies due to the employment of controlled mass transfer, flow and pressure reduction.

Benefits of CESS®

Controlled particle shape

Our nanoforming process can control the shape of particles, leading to greater uniformity.


Controlled particle size

Our technology can produce nanoparticles as small as 10 nm. Smaller particles have greater active surface areas, which permits an increased rate of dissolution.


Controlled polymorphism

Polymorphic purity tests have shown that stable single polymorphs can be produced with defined process parameters enabling polymorphic control.

Nanoform Finland Oy

  • FI
  • 2019
    On CPHI since
  • 1
    Certificates
  • 100 - 249
    Employees
Company types
Other

Nanoform Finland Oy

  • FI
  • 2019
    On CPHI since
  • 1
    Certificates
  • 100 - 249
    Employees
Company types
Other

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Nanoform Finland Oy resources (3)

  • Brochure Nanoform launches next-generation STARMAP ®️ v2.0, the AI-based drug candidate selection tool for CESS ®️

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  • Video Overcoming Drug Development Challenges with Nanotechnology

    This webinar originally aired as part of CPHI Discover - 17-28 May 2021 This session will focus on the application of nanotechnology to drug development, examining several areas of opportunity where current and emerging nanotechnologies could enable entirely novel classes of therapeutics. Gain perspective on the current status and the future growth and success of the field. New promising nanotechnology platforms to overcome drug development challenges to rapidly progress novel drugs to market. Specific applications of emerging interest in nanotechnology-based drug development systems The potential impact of Nanotechnology on the development of Personalized Medicine Increasing the possibilities and probabilities for Pharma using STARMAP AI technology Frontrunners within the particle engineering space - CESS® vs the rest Positive data from the first-in-human trial of a Nano-formed drug