SRL Secoya Technologies

About SRL Secoya Technologies

Are you facing issues with the chemical synthesis of API, its crystallization or micro-encapsulation ? Just contact us to discuss how our innovative solutions can help you. 

Secoya Technologies adapts the scale of industrial process equipment down to the ideal size in order to obtain an optimal control. Under these conditions, process parameters are precisely controlled. This results in a product exhibiting a strongly reduced polydispersity as well as a very low batch-to-batch variability. Furthermore, such conditions enable performance of processes that are not feasible in conventional batch reactors. 

Secoya's technologies are inherently compatible with continuous manufacturing processes. Based on flow process, the footprint of Secoya equipment is about the square meter reducing capital investment and operating costs.

Available technologies and expertise:
- Intensified (or continuous) chemical synthesis
- Pervaporation for the facile removal of a volatile component from a solution at low temperature
- Continuous Crystallization of small molecules
- Monodispersed micro-particles or core/shell capsules for API encapsulation 


  • BE
  • 2020
    On CPhI since
  • 1 - 24
    Employees
Contract Service
Engineering
Manufacturer/Innovator
Other
Contact info

Products from SRL Secoya Technologies

  • Continuous Crystallization Technology

    Product Continuous Crystallization Technology

    Production equipment for a controlled crystallization process.

    Through the use of small diameter capillaries, the crystallization tool of Secoya is able to master supersaturation conditions and control the nucleation process. By precisely selecting parameters, the nucleation rate can be adjusted to obtain the desired final crystal size, from 3 to 400 µm in a single crystallization step. Target morphism is easily achieved, as well as a narrow crystal size distribution. 

    As no physical micronisation is required, low crystal size powder exhibits an excellent flowability and thus excellent powder handling capacities.

  • Pervaporation Technology

    Product Pervaporation Technology

    Pervaporation is a liquid/liquid separation process using a selective and dense membrane. 

    By creating a vacuum or introducing a flow of purge gas on one side of a dense membrane, volatile compounds in the liquid present on the other side will selectively diffuse through the membrane. In addition to its high energetic efficiency, pervaporation is not subjected to azeotropic limitation, thanks to the use of a dense membrane. 


    The Secoya Pervaporation Tool is an attractive technology for various applications. For example:
    - Liquid/Liquid separation in the presence of a temperature sensitive (bio-)product; extraction of a component such as alcohol or water
    - For chemical & bio-processes: continuous removal of volatile compounds during fermentation, reaction, or to the feeding of reactants through the membrane.
    - Gas perfusion for bio-reaction.




  • Emulsification and Encapsulation Technology

    Product Emulsification and Encapsulation Technology

    On the basis of microfluidic principles, Secoya develops and supplies a novel emulsification technology – RayDrop®- for the production of monodispersed droplets or particles. 

    The emulsification process in the RayDrop® is based on co-flow and flow-focusing technologies embedded in a stainless-steel housing. Furthermore, the RayDrop® integrates the possibility to produce double emulsion (W/O/W, O/W/O), e.g. for the production of core/shell particles or capsules.

    Monodispersed PLGA particles are easily produced using the RayDrop® technology with particle size from 10 up to 200 µm and without the use of chlorinated solvent. The technology is suitable for the efficient encapsulation of any active ingredients, being either hydrophobic or hydrophilic, achieving an encapsulation efficiency exceeding 95%.

    Raydrop is perfectly suited for producing various types of particles, such as alginate, liposomes, ... with the desired particle size. 

    The RayDrop can be integrated into an emulsification platform to ease its use.  

  • Intensified Synthesis

    Product Intensified Synthesis

    As a service provider, Secoya develops new synthesis processes mostly based on flow chemistry. By downscaling reactor size, an optimal control of the process is achieved, enabling production of products with very high quality attributes. Secoya has a robust expertise in this field and has developed a methodical and holistic approach enabling the fast and efficient development of new chemical processes. These processes can then be integrated – or not – with certain Secoya technologies and are compatible with continuous and intensified production/manufacturing.

  • SCT-LAB

    Product SCT-LAB

    The SCT-LAB equipment is designed for a fast and accurate parameter sweep of crystallization conditions based on Secoya’s crystallization technology. Its comprehensive software enables the user for fast and easy use of the syringe pumps. As the software can be installed on external devices, the unit itself can be placed entirely in a glovebox, a fume hood, or other confined spaces, while the software can be manipulated externally. A defined protocol guides the user through the tests performing all necessary manipulations in the correct order to avoid any blockage occurring during the tests which may lead in extreme cases to a loss of insert or reactor. In between tests, the insert and reactor tubing are cleaned using a solvent of choice and/or air.
  • SET-LAB

    Product SET-LAB

    The emulsification platform is an integrative, fast and easy screening tool to set up emulsification processes such as simple and double emulsions using Secoya’s emulsification technology: the Raydrop. It includes a comprehensive flow path with pressure controllers, filters, flowmeters, and valves to ease the start-up, shut-down and cleaning of the system in between tests. A suitable optical system guarantees the optimum visualization of the emulsification process inside the Raydrop. The open design of the platform allows its adaptation to the customer’s needs. The Raydrop platform was developed with double emulsification process in its heart, but it is totally compatible with simple emulsification processes.

    This platform can guide you through your R&D projects, first screening etc. 

SRL Secoya Technologies Resources

  • Brochure General Company Presentation

    Secoya Technologies is a tech-provider for different domains (crystallization, single & double emulsification, encapsulation, pervaporation, process intensification) enabling the development as well as the production of (bio-)pharmaceutical products.


  • Brochure Robust and scaleable generation of mono-dispersed micro-spheres

    On the basis of microfluidic principles, Secoya develops and supplies a novel technology – RayDrop®- for the production of monodispersed droplets or particles. 

    The emulsification process in the RayDrop® is based on co-flow and flow-focusing technologies embedded in a stainless-steel housing. Furthermore, the RayDrop® integrates the possibility to produce double emulsion (W/O/W, O/W/O), e.g. for the production of core/shell particles or capsules.

    Monodispersed PLGA particles are easily produced using the RayDrop® technology with particle size from 10 up to 200 µm and without the use of chlorinated solvent. The technology is suitable for the efficient encapsulation of any active ingredients, being either hydrophobic or hydrophilic. 
  • Video How Secoya Technologies can help you in your process development activities.

    A brief overview of the problems in pharmacetucial production industry where Secoya Technologies can provide solution.
  • Video Continuous crystallization process

    In this introductory webinar, the Secoya Crystallization Technology is demonstrated. This technology focuses on the use of millifluidic capillary reactors that enable the most profound control on all crystallization parameters, making spontaneous nucleation controllable and exploitable. Several examples using organic molecules like active pharmaceutical ingredients are shown, also pinpointing to the way the nucleation can be controlled to crystallize the polymorphic form of choice and at the same time steer the process towards the final desired material attributes, especially size. As such, the complex multi-step process of crystallization (seed preparation, crystal growth, isolation, milling, etc.) is reduced to a simple setup where the nucleation, growth and isolation of organic or inorganic compounds are fully coupled from the (heated) solution to a crystalline material.