Video

The MUPS Compression Challenge: Solving Segregation

The particle size of the powder phase excipients is typically between 50 and 200 µm. Moreover, the bulk density of the pellet phase is greater than 0.7 g/cm3, whereas the density of the excipient mixture is 0.4–0.6 g/cm3. These significant differences in average particle size and density make a MUPS mixture extremely sensitive to segregation. It is, therefore, vital to maintaining blend uniformity during storage, transport, and feeding of the MUPS formulation into the tablet press, right up to when the blend is fed into the dies for compression. If segregation occurs during transfer, tablets could be produced with an out-of-specification (OOS) pellet concentration and, hence, an OOS API content. The content uniformity of the produced batch would subsequently fail quality assurance checks and the batch would need to be rejected...