• Home
  • Clariant
  • Effective Solubilization & Bioavailability Enhancement of Poorly Water Soluble APIs
Video
23 Nov 2021

Effective Solubilization & Bioavailability Enhancement of Poorly Water Soluble APIs

Watch Video

This session was originally broadcast as part of the CPHI Worldwide 2021 digital content programme.

Non-ionic solubilizers based on polysorbates, castor oil derivatives and poloxamer provide well established safety track record due to numerous OTC, Rx and dietary supplement products available on market. For formulators these classical solubilizers are first choice of excipients to improve the solubility and bioavailability of poorly soluble APIs.

The non-ionic solubilizers are proven very effective starting from simple o/w kind of formulations to innovative applications such as SEDDS, hot melt extrusion, spray drying etc. to improve the bioavailability of APIs. This session discusses:

  • Non-ionic solubilizers (VitiPure™ L 20, VitiPure™ O 80, VitiPure™ HCO 40, VitiPure™ CO 35, VitiPure™ P 188) to improve solubility and bioavailability of poorly soluble APIs
  • Well established safety & toxicology via several marketed drugs world-wide
  • Proven effective for all routes of administration and various pharmaceutical dosage form

    • Read more Show less
    Content provided by our supplier

    Clariant

    • CH
    • 2015
      On CPHI since
    • 2
      Certificates
    • 5000+
      Employees
    Company types
    Manufacturer/Innovator
    View company profile

    Other Content from Clariant (2)

    • Reimaging Chemistry to Improve Medicines: High Functional Excipients to increase APIs effectiveness

      Video Reimaging Chemistry to Improve Medicines: High Functional Excipients to increase APIs effectiveness

      In today’s world, medical innovations and pharmaceutical technology are essential drivers of human health: they open up the possibility of new treatments and subsequently act as a gateway which allows people around the world to access new medicines, improving their quality of life.

      In the production of pharmaceuticals, high-quality ingredients play a crucial role and must meet ever-increasing expectations in quality assurance to guarantee that safe, effective medicines reach the end consumer.

      Clariant Health Care is a leading high-quality solution partner for the global pharmaceutical industry, with a strong portfolio of top-performing excipients and active pharmaceutical ingredients (APIs), backed by operational excellence and years of experience in regulatory affairs.

      Explore Clariant’s high functional excipients to enable APIs bioavailability enhancement, controlled release, target delivery, stabilization, continuous manufacturing, preservation and viscosity enhancement.


      Click here to register

      2022-10-06
    • Widely Used Solvent with Stringent Control of Microbial Load

      Video Widely Used Solvent with Stringent Control of Microbial Load

      This session was originally broadcast as part of the CPHI Worldwide 2021 digital content programme. Low molecular weight Polyethylene glycols 300 & 400 are commonly used in formulations as solvents for APIs which are not soluble in water. For high-risk applications, stringent control of microbial load is essential. VitiPure™ LEX 300 and VitiPure™ LEX 400 offer relevant product specifications making them suitable for high-risk applications. This session explores: Low molecular weight PEG 300 (VitiPure™ LEX 300) and PEG 400 (VitiPure™ LEX 400) with Low microbial load for high-risk applications Surpass the current pharmacopoeia requirements Microbiological specifications support risk assessment in pharmaceutical and biopharmaceutical manufacturing
      2021-11-23