Trillium Provides Update on Anti-CD47 Cancer Program
Trillium Therapeutics provided an update on its lead cancer program - a SIRPaFc fusion protein targeting the CD47 pathway.
Trillium Therapeutics Inc. provided Wednesday an update on its lead cancer program - a SIRPaFc fusion protein targeting the CD47 pathway.
Trillium's SIRPaFc development candidate is a proprietary antibody-like fusion protein that blocks the activity of CD47, a molecule upregulated on many leukemias and solid tumors.
CD47 binds to SIRPa on the surface of macrophages, providing a "do not eat" signal that suppresses phagocytosis, allowing the cancer cells to escape immune-mediated destruction.
Elegant genetic experiments in mice have demonstrated that the CD47-SIRPa axis is critical for promoting the engraftment and dissemination of human leukemic
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