CPhI Online

Usin Near-Infrared spectroscopy and chemometric modeling to simultaneously determine ibuprofen and caffeine concentration in softgels

24 Sep 2020

Near-Infrared spectroscopy and chemometric modeling

Appearing in the September 2020 edition of Tablets & Capsules, this article summarizes a method for rapid and accurate determination of API concentration in the fill of soft gelatin capsules while little or no sample preparation. Applying chemometric models to near-infrared spectrum data allows scientists to predict the API content in samples from the manufacturing process and the final product.

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