Adolor Reports Positive Results from ADL5945 Phase II Studies
Adolor Corporation has received positive results from two Phase II studies of ADL5945 in chronic non-cancer pain patients with opioid-induced constipation.
Biopharmaceutical company Adolor Corporation has received positive top-line results from its two Phase II studies of ADL5945 in chronic non-cancer pain patients with opioid-induced constipation.
ADL5945, a peripherally-acting μ-opioid receptor antagonist, acts by blocking the adverse effects of opioid analgesics on the gastrointestinal tract without compromising centrally-mediated analgesia.
The two randomised, double-blind, placebo-controlled studies were identical in design. Study 242 evaluated 0.25mg and 0.10mg of ADL5945 administered twice daily, while Study 243 evaluated 0.25mg of ADL5945 administered once daily.
The primary endpoint of both s
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