AVI BioPharma Starts Eteplirsen Trial in Duchenne Muscular Dystrophy Patients
The study will evaluate the efficacy and safety of Eteplirsen in Duchenne muscular dystrophy patients over 24 weeks of dosing.
RNA-based therapeutics developer AVI BioPharma has launched patient dosing in a Phase II study of Eteplirsen for the treatment of Duchenne muscular dystrophy.
The 12-patient, placebo-controlled study is being conducted at Nationwide Children's Hospital in Columbus, Ohio, US, to evaluate the efficacy and safety of Eteplirsen in Duchenne muscular dystrophy patients over 24 weeks of dosing.
The efficacy endpoints include biochemical markers in muscle biopsies, such as the production of the dystrophin protein and markers of immune-inflammatory response, as well as clinical outcomes to measure muscle strength, function and degree of ambulation.
AVI CEO and president Chris Garabedian said the Ph
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