BioMarin Starts Phase 1 Study of BMN 673 for Advanced Hematological Malignancies
BioMarin Pharmaceutical has initiated a Phase I trial of a once-daily, oral poly-ADP-ribose polymerase inhibitor for advanced haematological malignancies.
BioMarin Pharmaceutical, a US based developer of biopharmaceuticals, is conducting a Phase I trial of a once-daily, oral poly-ADP-ribose polymerase inhibitor in patients with advanced haematological malignancies.
The two-arm, open-label dose escalation study of the drug, known as BMN 673, will involve around 80 patients across multiple sites in the US and the UK.
The study is intended to evaluate the maximum tolerated dose, safety, pharmacokinetics, pharmacodynamics and preliminary efficacy of the drug in patients with acute myeloid leukemia, myelodysplastic syndrome, chronic lymphocytic leukemia or mantle cell lymphoma.
BioMarin Pharmaceutical chief medical
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