Webinar
27 Jan 2024

Prefilled Ophthalmic Syringes - New Possibilities in Terminal Sterilization

Eric Offermann and Bernd Zeiss will speak about Nitrogen Dioxide (NO2) as a new sterilization method and an alternative to EtO gas. A joint study carried out by Gerresheimer, Sterigenics and Früh, showed that NO2 is well suited to terminally sterilize prefilled ophthalmic syringes. The following 5 topics will be addressed in detail:

  • Comparison of EtO vs. NO2 penetration into the filled syringe.
  • Analyze gas ingress through 4 different plunger stoppers including silicone oil-free and standard rubber plungers.
  • Scrutinize gas ingress through 2 different cap designs based on different elastomer properties.
  • Investigate gas permeation through COP plastic barrels compared to glass.
  • Check if the final blister has an influence on either sterilization method.
  • The ultimate objective of this study was to offer the best syringe design and packaging paired with the most suitable sterilization modality to pharma customers.

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    Sterigenics

    • US
    • 2016
      On CPHI since
    • 3
      Certificates
    Company types
    Contract Service

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