Hot Melt Extrusion (HME)

Hot melt extrusion (HME) is a proven technology for bioavailability enhancement of poorly soluble API's. Unlike other formulation options, hot melt extrusion technology is solvent-free. By drawing on continuous processing, it is also more economical and can be used for abuse deference and taste masking applications. This can ultimately deliver a higher quality, more marketable pharmaceutical product — in line with your commercialization strategy.

AbbVie advances your science like we would our own, with customized hot melt extrusion services that include:
Solubility/bioavailability enhancement, Support for good process control and scalability, Taste masking capabilities and Proven expertise in drug delivery
HOT MELT EXTRUSION PROCESS Using proprietary hot melt extrusion technology, AbbVie has successfully developed, scaled-up and commercialized many challenging chemical entities. The process involves distributing active pharmaceutical ingredients (APIs) through a specialized matrix to form a solid solution with known potency. Through this, hot melt extrusion can improve both drug efficacy and drug delivery efficiency. AbbVie Contract Manufacturing can then package your compound in a range of commercial dosage forms, including: Tableting/encapsulation, Potents (small concentrations), Controlled and modified release