Inhibitex Starts Dosing in Hepatitis C Drug Trial
The trial has been designed to evaluate three once-daily doses of INX-189 (25mg, 50mg and 100mg) administered in combination with pegylated interferon and ribavirin for 12 weeks.
US based biotechnology company Inhibitex has launched its dosing in a Phase II clinical trial to assess the safety, tolerability and antiviral activity of INX-189 in treatment naive patients who have chronic hepatitis C virus genotype 2 or 3.
INX-189 is a protide of a 2'-C-methyl guanosine analogue. Preclinical and clinical studies demonstrated INX-189 as a potent, once-daily, low dose oral therapy amenable to combination with other antivirals for the treatment of patients with all known genotypes of hepatitis C.
The 90-patient, randomised, placebo controlled and treatment guided trial has been designed to evaluate three once-daily doses of INX-189 (25mg, 50mg and 100mg) administered in combination with pegylated interferon and ribavirin for 12 weeks.
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