Melt Extruded Amorphous Formulations of Poorly Bio – Available Immunosuppressants25 Nov 2017
Alphie mixer was used in study of “Melt Extruded Amorphous Formulations of Poorly Bio – Available Immunosuppressants”
The current status of organ transplantation and the post-operative care using immunosuppressants brings us to the drugs that play a pivotal role in prevention of transplant rejection. Two potent immunosuppressant drugs, tacrolimus and sirolimus were chosen to be formulated using the easily scalable and environment friendly Hot Melt Extrusion (HME) method. Study was made to develop formulations of these two drugs, characterize them and to study their dissolution profiles and storage stability.
For Oral Dispersible Tablets (ODT) containing solid dispersion of tacrolimus, The physical mixtures were prepared by weighing out the polymer and API and mixing by geometrical mixing using Alphie powder mixer to ensure homogeneity.
Are you a supplier?
Here's what CPhI Online can do for you
- Generate quality leads for your business
- Stay visible for 365 days of the year
- Receive product inquiries and respond to meeting requests directly
- Improve company online presence through Search Engine Optimisation