Post purification sample handling
Genevac has developed a suite of proprietary technological solutions to facilitate post purification sample handling, including reformatting.
Genevac has developed a suite of proprietary technological solutions to facilitate post purification sample handling, including reformatting.
For labs undertaking purification using Normal Phase HPLC, SFC or Flash chromatography, removal of organic solvents can be simply, productively and safely done in a Genevac centrifugal evaporator (EZ-2, ROCKET, Rocket Synergy or HT Series III). Where the nature of the sample being concentrated can lead to solvent bumping (e.g., natural products), Genevac's DriPure technology is proven to completely eliminate this troublesome and time-consuming problem.
The evaporation of aqueous acetonitrile (or methanol / ethanol) fractions resulting from Reverse Phase HPLC is a widely carried out application on many Genevac evaporator systems. A multiple stage method has been developed for the EZ-2 evaporator to remove the organic solvent without freezing the water, remove the water, and then dry any remaining stubborn solvent. Alternatively, the unique LyoSpeed fast lyophilisation method can be used in Genevac HT series evaporators to produce dry (solvent-free) powders from samples that previously could only be produced as gums and oils. Recent advances in condenser technology, in particular the high power -75 °C cold trap, available on HT Series III and Rocket Synergy evaporators, has led to significant advances in lyophilisation success rates.
During post purification handling, samples typically need to be reformatted from fraction tubes or flasks, into a small vial for compound storage. For this specific time consuming task, Genevac developed SampleGenie technology. SampleGenie enables a large volume to be dried (or lyophilised) directly into a small storage vial in a fraction of the time taken by traditional evaporation methods that require you to reformat samples from a flask or multiple tubes into a vial.
Related News
-
News Patients vs Pharma – who will the Inflation Reduction Act affect the most?
The Inflation Reduction Act brought in by the Biden administration in 2022 aims to give better and more equitable access to healthcare in the USA. However, pharma companies are now concerned about the other potential costs of such legislation. -
News CPHI Podcast Series: What does the changing US Pharma market mean for industry and patients alike?
In this week's episode of the CPHI Podcast Series Lucy Chard, Digital Editor for CPHI Online is joined by James Manser to discuss the political and market changes in the US pharma field. -
News CPHI Barcelona Annual Report illuminates industry trends for 2024
The CPHI Annual Survey comes into it’s 7th year to report on the predicted trends for 2024. Over 250 pharma executives were asked 35 questions, with their answers informing the industry landscape for the next year, spanning all major pharma marke... -
News Which 10 drugs are open to price negotiation with Medicare in the USA?
The Centres for Medicare & Medicaid Services, under the Biden administration in the USA, has released a list of the 10 drugs that will be open to price negotiations as part of the new legislation under the Inflation Reduction Act (IRA). -
News EU Medical Devices Regulation causes unintended disappearances of medical devices for children, doctors state
Doctor groups and associations have appealed to the EU to correct the EU Medical Devices Regulation law that may cause unintended shortages of essential drug and medical devices for children and rare disease patients. -
News 10 Major Drug Approvals So Far in 2023
Last year, 37 novel drugs were approved by the FDA, this was a high number for such a category, and covered many fields including oncology, demonstrating how promising further research is, and how it is only continuing to build. To date, there are alre... -
News Detecting Alzheimer's disease with a simple lateral flow test
A novel rapid diagnostic test for early-stage Alzheimer's disease has been developed using a biomarker binder from Aptamer Group along with technology from Neuro-Bio, the neurodegenerative disease experts. -
News CPHI Podcast Series: outsourcing and manufacturing trends
Listen to the CPHI Podcast Series this June to hear Gil Roth of the PBOA speak with Digital Editor Lucy Chard about the biggest trends and topics to watch in pharma outsourcing and manufacturing at the minute.
Position your company at the heart of the global Pharma industry with a CPHI Online membership
-
Your products and solutions visible to thousands of visitors within the largest Pharma marketplace
-
Generate high-quality, engaged leads for your business, all year round
-
Promote your business as the industry’s thought-leader by hosting your reports, brochures and videos within your profile
-
Your company’s profile boosted at all participating CPHI events
-
An easy-to-use platform with a detailed dashboard showing your leads and performance