Ribociclib Series

Ribociclib Series
Product Description

a cyclin-dependent kinase (CDK) inhibitor that targets cyclin D1/CDK4 and cyclin D3/CDK6 at nanomolar concentrations. It inhibits retinoblastoma protein phosphorylation, which prevents CDK-mediated G1-S phase transition, arresting the cell cycle in the G1 phase, suppressing DNA synthesis, and inhibiting cancer cell growth. LEE011 has been shown to reduce proliferation in 12 of 17 human neuroblastoma-derived cell lines by inducing cytostasis (mean IC50 = 306 nM in sensitive lines).

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Tianjin Pharmacn Medical Technology Co., Ltd.

  • CN
  • 2015
    On CPHI since
  • 2
    Certificates
  • 250 - 499
    Employees
Company types
Biopharmaceutical company
Manufacturer/Innovator
Pharmaceutical company
Primary activities
API Producer
Intermediates Manufacturer
View company profile
Specifications
  • CAS Registry Number
    1211441-98-3
  • Details
    Boiling point:730.8±70.0 °C(Predicted)Density：1.39±0.1 g/cm3(Predicted)
    vapor pressure: 0-0Pa at 20-25℃ 
    storage temp： -20°C
    solubility： Soluble in DMSO (up to 10 mg/ml)
    pka：8.67±0.10(Predicted)
    form: solid
    color： Off-white
    MF: C23H30N8O 
    MW:434.54 
    EINECS:807-111-0
  • Selling Points
    International Approvals/Standards; Price; Prompt Delivery; Quality Service; Reputation; Small Orders Accepted; Sustainability; Products will not be supplied to countries in which they would be in conflict with the valid patents and will only be offered to the R&D projects.
  • Supplied from
    China
  • Measured In
    kilogram
More specifications Fewer specifications
Sales Markets
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Tianjin Pharmacn Medical Technology Co., Ltd.

  • CN
  • 2015
    On CPHI since
  • 2
    Certificates
  • 250 - 499
    Employees
Company types
Biopharmaceutical company
Manufacturer/Innovator
Pharmaceutical company
Primary activities
API Producer
Intermediates Manufacturer
View company profile

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Tianjin Pharmacn Medical Technology Co., Ltd. resources (1)

  • Product Brochure

    Brochure Product Brochure

    Tianjin pharmacn medical technology co ltd offers Apis, pharmaceutical intermediates and fine chemicals. Contact us for more information.