Tigris Starts Randomized Phase 2 Study of AFP-464
The primary endpoint of the study is to determine the percentage of patients that achieve a Clinical Benefit Response.
Tigris Pharmaceuticals, Inc., a privately held biopharmaceutical company, has announced enrollment of its first patient in a randomized Phase 2 clinical trial of AFP-464 (aminoflavone prodrug) with or without Faslodex? (fulvestrant) in estrogen receptor (ER)-positive breast cancer patients.
Molecular profiling will be used to pre-screen patients for a biomarker called Aryl Hydrocarbon Receptor (AhR), which has shown to predict sensitivity to AFP-464.
"The promise of personalized medicine is being realized with this study of AFP-464," said Edmundo Muniz, M.D., Ph.D., president and chief executive officer of Tigris Pharmaceuticals. "Matching specific markers and gene variations to particular medicines is a more efficient way of developing
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