Whitepaper

Sodium Alginate for Anti-reflux Suspensions – Study of Effect of Alginate Quality and Formulation Variables

Sodium Alginate for Anti-reflux Suspensions – Study of Effect of Alginate Quality and Formulation Variables

Treatment for GERD (gastroesophageal reflux disease) is generally targeted for gastric acid neutralization and suppression of gastric acid production and/or secretion. However, another key approach to alleviate the condition is minimizing the exposure of the esophagus to acidic refluxate via raft-forming anti-reflux preparation wherein a viscous gel forms a physical barrier above the stomach contents and prevents it from refluxing back into the esophagus. This whitepaper from DuPont provides key insights into how sodium alginate acts as the key functional ingredient in anti-reflux formulations but also how the combined functionality of all ingredients creates the raft forming function via optimum concentration in formulation.