The 3M™ Emphaze™ AEX Hybrid Purifier is a synthetic, multi-mechanism single-use purifier used for biopharmaceutical clarification. It delivers consistent, high purity clarified process fluid by removing soluble and insoluble impurities, such as DNA, HCP, and celldebris, through a combination of chromatographic and size exclusion mechanisms.
Customers experience benefits in typical monoclonal antibody purification processes:
• Nominal 30% HCP and greater than 4 log DNA reduction.
• Consistent output turbidity (<5 NTU).
• Increase product purity post-protein A.
• Downsizing of the sterilizing grade membrane.
• Reduce turbidity post viral inactivation/neutralization step.
• Reduce impurities load on downstream AEX column.
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