Datwyler Pharma Packaging Belgium NV

UltraShield(TM) is the contemporary solution from Datwyler providing excellent drug compatibility and cold storage capabilities. _x000D_ Its modern bromobutyl rubber substrate coated with a fluoropolymer film forms a protective barrier that minimises extractables and offers ultra-protection against aggress...

Large Volume Subcutaneous Injections How Datwyler’s Innovative Plunger Portfolio Addresses the Latest Trends in Drug Delivery

Datwyler is the preferred solution partner to global pharmaceutical companies. We offer one of the most extensive product portfolios for vial applications in the pharmaceutical and biotech markets worldwid. Our range of products and services includes the most innovative elastomer formulations, coatings, al...

We offer our customers a broad portfolio of the highest quality sealing solutions for their syringe systems. This includes elastomeric plunger stoppers, needle shields, and tip caps to seal the prefilled syringes as well as plungers and rubber-lined aluminum seals to ensure system integrity.

The rising prevalence of Biologics and other sensitive therapeutics in clinical practice, associated to the transitional trend from hospital to home administration are rapidly modifying the landscape of subcutaneous (SC) drug delivery. Such route of administration (SC) empowers patients with the ability to self-administer at home, reducing the burden of frequent clinic visits and supporting the growing shift toward decentralized, patient-centric healthcare.
Traditionally, SC injections have been limited to low volumes (typically ≤2 mL) due to concerns over pain, tissue tolerability, and absorption kinetics. However, emerging therapies—particularly monoclonal antibodies, anti-cancer treatments, and long-acting neurologic formulations—often require higher doses that cannot be feasibly delivered subcutaneously within these conventional volume constraints. Consequently, there is a growing demand for innovative solutions supporting self-administration of larger volumes, without compromising safety, therapeutic efficacy and compliance. Sensing such market pressure, Datwyler has already started to extend its range of NeoFlex™ plungers to complete larger containers, supporting the novel on-body injectors, designed for slow, controlled delivery, expanding the feasible range of SC administration volumes.
A collaborative and open approach among the parties involved with the development of the container closure system (CCS) and the device allows the optimization of pre-verified platform solutions, so to accelerate their time to market and, ultimately, availability to the Patients.