Sanisure

Small-Volume Single-Use Mixing Platform We are changing the game for small-volume mixing with Mixed4Sure™—the best single-use, out-of-the-box bottle and carboy mixing platform specifically designed for commercial biopharmaceutical mixing. CHANGING THE GAME FOR SMALL-VOLUME MIXING Mixed4Sure™ enables cont...

RNase/DNase-free PETG bottles and carboys with ultra-low particulate and endotoxin specifications for sensitive biologics and advanced modalities. PETG PharmaTainer is a platform of ready-to-use, square PETG bottles and carboys that combine exceptional cleanliness, 10-6 sterility assurance, and comprehens...

Traditional fixed or tethered pressure sensors offer unique advantages over single-use pressure sensors in terms of accuracy, simplicity, and reliability. The aSURE™ instrument fitting eliminates the need for single-use pressure sensors and offers the flexibility to choose virtually any 1.5″ sanitary press...

Reliability by DesignHow Engineered Reliability Is Reshaping Single-Use Bioprocessing


How custom assembly design, vertical integration, and regulatory alignment are becoming one standard for single-use fluid management.

Custom assembly design, vertically integrated supply, and proactive regulatory alignment are converging into a single standard of performance for single-use bioprocessing assemblies in biopharmaceutical manufacturing – shifting reliability from something you verify after the fact to something engineered in from the start.

Mixed4Sure™ enables continuous mixing at all process volumes from 50 mL — 20 L. It also maintains mixing and fluid homogeneity during offload down to 50ml, which ensures the consistency of your drug is maintained down to the last drop. In downstream mixing steps, shear forces can have undesirable effects on your sensitive protein, such as degradation and aggregate formation. Mixed4Sure™ has been shown to create only ½ the shear forces of a comparable mixing system, and a magnitude of 4 lower than the forces leading to protein degradation.

In biologics production, mixing operations are crucial for maintaining fluid homogeneity. However, shear stress during mixing can affect protein stability and quality attributes. Understanding how mixer design and process parameters influence shear force generation is essential for product integrity. Computational Fluid Dynamic (CFD) modeling during product development demonstrated that the Mixed4Sure™ Bottom Mount impeller design outperformed traditional stir bars. Subsequent laboratory evaluation using lysozyme as a protein model confirmed these findings. This session will highlight the importance of innovative mixer designs in optimizing protein formulation processes that will help you maintain product quality. During the session, the following key takeaways will be discussed: CFD modeling revealed superior mixing performance of the new impeller geometry Laboratory studies validated the CFD predictions The Mixed4Sure™ Bottom Mount demonstrated lower shear stress compared to conventional stir bars, indicating improved mixing performance in shear sensitive process steps.