Whitepaper
6 Sep 2023
ANALYTICAL TOOLS & TECHNIQUES IN HOT MELT EXTRUSION - CASE STUDY ON PROCESS SCALE UP
PDF 1.4 MB
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Sever Pharma Solutions
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SE
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2023On CPHI since
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250 - 499Employees
Company types
Other Content from Sever Pharma Solutions (1)
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Whitepaper A COMPARISON OF SATURATED SOLUBILITY ENHANCEMENT VIA SPRAY DRYING AND HOT MELT EXTRUSION PROCESSING
Solid solutions are similar to liquid solutions and consist of a single phase irrespective of the number of components. A solid solution of a poorly water-soluble drug dissolved in a carrier is particularly interesting in improving oral bioavailability. In a solid solution, the drug’s particle size has been reduced to its molecular dimensions resulting in a more rapid dissolution rate. By judicious selection of a carrier, the dissolution rate of the drug can be increased by up to several orders of magnitude. In a solid solution, the drug’s particle size has been reduced to its molecular dimensions resulting in a more rapid dissolution rate.
This whitepaper compares solubility enhancement between spray drying and hot melt extrusion for a poorly soluble, new active pharmaceutical ingredient.
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