Application of mini ODTs and coin shaped ODTs with Daicel's excipients for pediatric preparation

GRANFILLER-D™ is a co-processed excipient for direct compression ODTs. ODTs with GRANFILLER-D™ provide:Well balanced properties between tablet hardness and disintegration timeHigh dosing capacity of active pharmaceutical ingredients (APIs)Good content uniformity of APIs

In this article, we report preparation of bilayer ODTs using GRANFILLER-D™ and direct compression which are less prone to delamination.

 In this study, we verified applicability of orally disintegrating tablets (ODTs) to continuous manufacturing. We produced ODTs with our co-processed excipient, which is HiSORAD™, by applying dry granulation process. 

HiSORAD™ is a state-of-the-art co-processed excipient for orally disintegrating tablets designed to have well-balanced property between orally disintegration time and tablet hardness. HiSORAD™ enables to produce ODTs by direct compression with three advantages: Practical flowability, excellent compactability and rapid disintegration.