Refining the Antibody Capture Process: Innovations for Enhanced Purity and Efficiency With Modern Affinity Resins

This presentation examines evolving therapeutic antibody processes. Processing of conventional mAbs continues to mature, while new chromatography approaches are required for multispecifics and fragments—as a one-size-fits-all strategy has become outdated. Optimizing capture requires selecting processes based on the target molecule, development stage, scale-up plans, and budgets. Moreover, antibody variants are challenged with aggregation and product-related impurities. We will evaluate strategies focused on resin selection, operation mode, and process conditions to boost purity, yield, and productivity, including new protein A resins.