Medivation & Pfizer to Discontinue Dimebon Development
Medivation and Pfizer will discontinue development of dimebon for all indications and will terminate the ongoing open label extension study in Alzheimer's disease.
Medivation, Inc. and Pfizer Inc. has announced results from the CONCERT trial, which is a Phase 3 trial that evaluated dimebon (latrepirdine) when added to ongoing treatment with donepezil HCL tablets in patients with mild-to-moderate Alzheimer's disease.
Dimebon did not achieve statistically significant results for either of the two co-primary endpoints, the Alzheimer's Disease Assessment Scale - cognitive subscale (ADAS-cog), which measures cognitive ability, or the Alzheimer's Disease Cooperative Study - Activities of Daily Living (ADCS-ADL), which measures self care and daily function.
"We are disappointed in the CONCERT results and the implications for Alzheimer’s disease patients and their caregivers,"
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